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| Test Code: |
FACT2 |
| Description: |
Factor II (prothrombin) is a vitamin K-dependent clotting factor, which in the presence of prothrombinase (composed of factors Xa and Va on a phospholipid surface) is converted to thrombin (factor IIa). Thrombin is a central molecule in the coagulation process. In addition to converting fibrinogen into fibrin clot and activating factor XIII (which cross-links fibrin clot), thrombin amplifies the clotting cascade by activating co-factors V and VIII. In the presence of thrombomodulin, thrombin limits coagulation by activating protein C, which inactivates co-factors Va and VIIIa. Thrombin is also a potent activator of platelets. Congenital hypoprothrombinemia is a rare disease inherited in an autosomal recessive pattern. Acquired hypoprothrombinemia occurs in a subset of patients with lupus anticoagulants. |
| Indications: |
Suspected factor II deficiency or inhibitor, vitamin K deficiency |
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