| Description: |
FDP, FSP, Fibrin Split Products. Fibrin/fibrinogen degradation products (FDP) are the result of the breakdown of fibrinogen (primary fibrinogenolysis) and fibrin (fibrinolysis). The FDP test detects de gradation products generated by the action of thrombin on fibrinogen (primary fibrinogenolysis) and the action of plasmin on fibrin (fibrinolysis). In contrast, the D-Dimer detects breakdown products that are only generated by the action of plasmin on stabilized fibrin. The two tests together can be useful for evaluating suspected cases of primary fibrinogenolysis. In this instance, the FDP will be positive while the D-Dimer is normal. In DIC, both will be prolonged. FDPs are normally cleared rapidly from circulation. When present in large quantities, FDPs can interfere with the hemostatic process through several avenues: forming soluble complexes with fibrin monomer which prohibits the fibrin monomer from polymerizing, antithrombin activity, and by binding to platelet surfaces thereby interfering with platelet function. Increased FDPs are seen in disseminated intravascular coagulation (DIC), severe liver disease, cirrhosis, eclampsia, thrombotic episodes, after surgery or trauma, and following lytic therapy. |
