The most common hemoglobinopathies are related to sickle cell syndromes and various types of thalassemia. Intermittent or episodic hemolysis similar to that seen in G6PD deficiency also can occur with unstable hemoglobins such as Hemoglobin H. In addition, hemoglobin studies are indicated in assessing individuals who have microcytosis not due to iron deficiency. These studies will detect alpha and beta thalassemia trait and the clinical disorders associated with Hemoglobin E.

In addition to hemoglobin analysis, confirmatory and/or prenatal testing for alpha globin gene deletions and beta globin gene mutations are offered by the Stanford Molecular Pathology Laboratory. These tests may be added to Hemoglobin HPLC specimens when requested by the ordering physician. See Molecular Genetic Pathology Testing Section.