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| Test Code: |
PROTS |
| Description: |
Protein S functional. Protein S is a vitamin K-dependent co-factor for activated protein C, which serves to inactivate factors Va and VIIIa. Protein S deficiency is clinically indistinguishable from protein C deficiency, with heterozygous individuals at an increased risk of recurrent venous thrombosis. |
| Indications: |
The assay is useful for evaluation of thrombophilic patients, in particular those who have a family history of thrombosis, thrombosis at a young age (<40 years), recurrent thrombosis or thrombosis at unusual sites (inferior vena cava, mesenteric veins). Normal neonates have lower protein S levels than adults do. Patients with the factor V Leiden mutation may have artificially low functional protein S levels. |
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